近日，美国斯坦福大学Mark Kasevich团队研究了体内自旋相关自由基对动力学的磁共振控制。相关论文于2026年3月18日发表在《自然》杂志上。

磁场可影响涉及自旋相关自由基对（SCRPs）的化学反应。这一机制揭示了静态和时变磁场如何在生物分子层面影响生命系统。然而，目前尚未有研究在多细胞生物体中构建工程化SCRP系统，使其赋予非原生生化过程磁场敏感性。

研究组展示了在活体转基因动物中利用磁共振调控SCRP动力学的成果。研究表明，在黄素辅因子存在条件下，通过施加电子自旋共振频率附近的静态与射频组合磁场，可改变多种红色荧光蛋白（RFPs）的发射特性。该效应在室温条件下分别于体外实验和经基因改造表达mScarlet4红色荧光蛋白的秀丽隐杆线虫体内得到验证。

这些观测结果表明，RFP-黄素体系中检测到的磁场效应源于量子相干自由基对，其相干时间超过4纳秒。该实验证实射频磁场能够影响活体内SCRP参与的反应动力学，为基因表达等生物分子过程的远程控制开辟了新途径，并揭示了量子生物学工具更广阔的应用前景。

附：英文原文

Title: Magnetic resonance control of spin-correlated radical pair dynamics in vivo

Author: Burd, Shaun C., Bagheri, Nahal, Condon, Alec F., Ingaramo, Maria, Mondal, Samsuzzoha, Dowlatshahi, Dara P., Summers, Jacob A., Mukherjee, Srijit, York, Andrew G., Wakatsuki, Soichi, Boxer, Steven G., Kasevich, Mark

Issue&Volume: 2026-03-18

Abstract: Magnetic fields can influence reactions involving spin-correlated radical pairs (SCRPs)1,2. This provides a mechanism by which both static and time-varying magnetic fields can affect living systems at the biomolecular level3. However, an engineered SCRP system conferring magnetic sensitivity to a non-native biochemical process in a multicellular organism has not yet been demonstrated. Here we demonstrate control of SCRP dynamics using magnetic resonance in a live transgenic animal. We show that the emission of various red fluorescent proteins (RFPs), in the presence of a flavin cofactor, can be modified by a combination of static and radiofrequency magnetic fields applied near the electron spin resonance frequency. This effect was measured at room temperature both in vitro and in the nematode Caenorhabditis elegans, genetically modified to express the RFP mScarlet4. These observations suggest that the magnetic field effects measured in RFP-flavin systems5 are due to quantum-correlated radical pairs with a coherence time larger than 4ns. Our experiments demonstrate that radiofrequency magnetic fields can influence dynamics of reactions involving SCRPs in vivo, potentially enabling new methods for remotely controlling biomolecular processes, such as gene expression, and suggest broader potential for quantum tools in biology.

DOI: 10.1038/s41586-026-10282-4

Source: https://www.nature.com/articles/s41586-026-10282-4