2026年6月17日出版的《自然》杂志发表了中国科学家的一项最新研究成果。来自西湖大学的郭天南小组的研究开发出了蛋白质组在人体和癌症中的空间分布。

在这里，该研究组提出了一个全面的人类蛋白质组学景观，通过分析超过13000个蛋白质在2856个样品主题数据独立采集质谱生成。该数据集涵盖58种主要组织类型、251种特定组织亚型和25种不同的癌症。这种阻力使得描述跨组织类型和生理状态（包括胎儿、肿瘤、邻近非肿瘤和健康成人组织）的空间分辨蛋白质组轨迹成为可能，从而提供对发育过程和致癌进展的洞察。

此外，不同组织类型和状态的定量蛋白质组学比较有助于器官特异性毒性的指示，确定可重复使用的抗癌候选药物以及癌症治疗靶点的优先级。这项研究建立了在人体和常见癌症中导航蛋白质组的定量抗性。

据介绍，详细的、空间分辨的人类蛋白质组定量图谱对于更深入地了解人类生物学和疾病至关重要。

附：英文原文

Title: Spatial distribution of the proteome in the human body and in cancers

Author: Yue, Liang, Jiang, Wenhao, Li, Sainan, Luo, Meng, Fan, Ning, Zhan, Xiaolu, Sun, Rui, Cheng, Honghan, Xue, Zhangzhi, Liu, Tong, Zhou, Qianhe, Chen, Kexin, Lu, Tian, Guo, Fang, Li, Dongwei, Ge, Weigang, Nie, Zongxiang, Lyu, Mengge, A, Jun, Wang, Yingrui, Chen, Yingdan, Fu, Zhenhai, Xiang, Nan, Li, Lu, Yu, Fengchao, Teo, Guo Ci, Nesvizhskii, Alexey I., Wang, Meng, Snyder, Michael P., Collins, Ben C., Xiao, Qi, Aebersold, Ruedi, Xu, Fei, Yang, Hui, Zhang, Sijia, Han, Yi, Zhu, Yi, Ji, Yong, Li, Yan, Guo, Tiannan

Issue&Volume: 2026-06-17

Abstract: A detailed, spatially resolved quantitative map of the human proteome is essential for a deeper understanding of human biology and disease1,2,3,4. Here we present a comprehensive human proteomic landscape, generated by profiling more than 13,000 proteins across 2,856 samples using data-independent acquisition mass spectrometry. The dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. This resource enables the depiction of spatially resolved proteome trajectories across tissue types and physiological states, including fetal, tumour, adjacent non-tumour and healthy adult tissue, thereby providing insight into both developmental processes and oncogenic progression. Furthermore, quantitative proteomics comparisons across diverse tissue types and states facilitate the indication of organ-specific toxicity, the identification of repurposable anticancer drug candidates and the prioritization of therapeutic targets for cancers. This study establishes a quantitative resource for navigating the proteome in the human body and in common cancers.

DOI: 10.1038/s41586-026-10660-y

Source: https://www.nature.com/articles/s41586-026-10660-y

期刊信息

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504

官方网址：http://www.nature.com/

投稿链接：http://www.nature.com/authors/submit_manuscript.html